Synthesis of 3-trifluoromethylfurans from β, β-bis (trifluoromethyl) α, β-unsaturated ketones and tin (II) chloride

K Burger, B Helmreich

Index: Burger, Klaus; Helmreich, Brigitte Journal of the Chemical Society, Chemical Communications, 1992 , # 4 p. 348 - 349

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Citation Number: 16

Abstract

The development of synthetic methodologies for the selective introduction of short chain perfluoroalkyl groups into organic molecules is of current interest because of their ability to enhance biological activity. I The building block strategy for introduction of perfluoroalkyl groups is often found to be superior to a selective introduction of the fluorinated side chain in a final step of the reaction sequence. In the case of five-membered heteroaromatic compounds some effective ...