Tetrahedron

Convenient one-step synthesis of 4-unsubstituted 2-amino-4H-chromene-2-carbonitriles and 5-unsubstituted 5H-chromeno [2, 3-b] pyridine-3-carbonitriles from …

VA Osyanin, DV Osipov, YN Klimochkin

Index: Osyanin, Vitaly A.; Osipov, Dmitry V.; Klimochkin, Yuri N. Tetrahedron, 2012 , vol. 68, # 27-28 p. 5612 - 5618

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Citation Number: 16

Abstract

We have reported DBU catalyzed synthesis of 4-unsubstituted 2-amino-4H-chromene-2- carbonitriles in water under reflux. The attractive features of this process are mild reaction conditions, short reaction times, easy isolation of products and good yields. 5H-chromeno [2, 3-b] pyridine-3-carbonitriles were obtained by refluxing excess of malononitrile and quaternary ammonium salts in ethanol in the presence of NaOH as catalyst. The ...

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