First hydrogen abstraction-rearrangement model for the coenzyme B12-dependent methylmalonyl-CoA to succinyl-CoA carbon skeleton rearrangement reaction

P Dowd, B Wilk, BK Wilk

Index: Dowd, Paul; Wilk, Boguslawa; Wilk, Bogdan K. Journal of the American Chemical Society, 1992 , vol. 114, # 20 p. 7949 - 7951

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Citation Number: 29

Abstract

This model makes it possible to compare the outcome of reactions originating from the carbon-cobalt bonded intermediate with those from free radical initiated ones. Moreover, free radicals in this series can be generated by two independent means. In one approach, the carbon-cobalt bonded adduct 3 was photolyzed at 27 OC in water under Ar yielding mainly the direct reduction product 10 (go%), but the rearrangement product 8 was ...