Analytical Chemistry

Conformational effects in reversed-phase liquid chromatographic separation of diastereomers of cyclic dipeptides

N Funasaki, S Hada, S Neya

Index: Funasaki, Noriaki; Hada, Sakae; Neya, Saburo Analytical Chemistry, 1993 , vol. 65, # 14 p. 1861 - 1867

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Citation Number: 13

Abstract

The capacity factors, k', of 11 cyclic dipeptides (XY) including diastereomers have been determined on an RP-HPLC column in 30% and 50% methanol and lo%, 30%, and 50% acetonitrile solutions. These factors are roughly correlated with hydrophobic parameters, such as octanolwater partition coefficients estimated and k 'values for alcohols. For a pair of diastereomers of cyclic (LXL-Phe) and (LXD-Phe) derivatives k% L is larger than k'LD, and ...