Steroids

Antihormonal properties of some new A-homo-B, 19-dinor steroids of the androstane series

A Kasal, R Hampl, M Bičíková, L Stárka

Index: Kasal, Alexander; Hampl, Richard; Bicikova, Marie; Starka, Luboslav Steroids, 1992 , vol. 57, # 9 p. 460 - 463

Full Text: HTML

Citation Number: 5

Abstract

Abstract On solvolysis of Westphalen-type steroids with a leaving group in the position 6β (eg, 2), products of elimination (followed by rearrangement and fragmentation of the steroid skeleton) were prepared (eg, 4 and 5). These products were subsequently converted to suitable analogs of the compound, which has been reported to promote hair growth (1). Compounds 11 to 13 exhibited strong antiandrogenic activity in vivo; however, this activity ...