Synthesis and cardiotonic activity of novel biimidazoles

DP Matthews, JR McCarthy, JP Whitten…

Index: Matthews, Donald P.; McCarthy, James R.; Whitten, Jeffrey P.; Kastner, Philip R.; Barney, Charlotte L.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 317 - 327

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Citation Number: 42

Abstract

(DOH) inhibitor, 2, 2'-bi-lH-irnidazole (lp7 cardiotinic activity was observed? After the administration of a single 10 mg/kg oral dose to conscious monkeys, inotropic activity as measured by dP/dt, increased 78%. Additional studies indicated the inotropic effects were attributable to a metabolite of 1, of unknown structure. These observations and the report that imidazole increases myocardial contractilityg prompted us to further investigate ...