Regio-and stereoselective reductions of dehydrocholic acid

G Cravotto, A Binello, L Boffa, O Rosati, M Boccalini…

Index: Cravotto, Giancarlo; Binello, Arianna; Boffa, Luisa; Rosati, Ornelio; Boccalini, Marco; Chimichi, Stefano Steroids, 2006 , vol. 71, # 6 p. 469 - 475

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Citation Number: 7

Abstract

Dehydrocholic acid (DHCA), an unnatural bile acid, is manufactured by oxidation of cholic acid. Its biotransformation by two basidiomycetes (Trametes hirsuta and Collybia velutipes) is reported. These mycelia showed different affinities for the substrate and selectivities of attack: T. hirsuta in particular regio-and stereoselectively reduced the 3-keto group to yield 3α-hydroxy-7, 12-diketo-5β-cholan-24-oic acid (7, 12-diketolithocolic acid) as the main ...