Tetrahedron Letters

Efficient methods for the synthesis of α-aminophosphonate fluoroalkyl esters

M Skoreński, J Oleksyszyn, M Sieńczyk

Index: Skorenski, Marcin; Oleksyszyn, Jozef; Sienczyk, Marcin Tetrahedron Letters, 2013 , vol. 54, # 12 p. 1566 - 1568

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Citation Number: 3

Abstract

Two novel synthetic methods for the preparation of bis (trifluoroethyl) esters of α- aminophosphonic acids are presented. Preliminary results on the application of the compounds synthesized as inhibitors of serine proteases are also reported. Structures originating from α-aminoalkylphosphonate diaryl esters represent a novel class of serine protease inactivators.