A facile stereoselective synthesis of 2-perfluoroalkyl-3a, 4, 5, 6-tetrahydroimidazo [1, 5-b] isoxazoles

L Lu, W Cao, J Chen, H Zhang, J Zhang, H Chen…

Index: Lu, Lei; Cao, Weiguo; Chen, Jie; Zhang, Hui; Zhang, Jiaping; Chen, Huiyun; Wei, Jiamei; Deng, Hongmei; Shao, Min Journal of Fluorine Chemistry, 2009 , vol. 130, # 3 p. 295 - 300

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Citation Number: 17

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Methyl 2-perfluoroalkynoates 2 reacted readily with cyclic nitrones 1 via 1,3-dipolar cycloaddition at room temperature to give 2-perfluoroalkyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazoles 3 in good to excellent yields with high diastereoselectivity and regioselectivity. ...

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