Indole based cyclooxygenase inhibitors: Synthesis, biological evaluation, docking and NMR screening

…, A Viegas, J Manso, S Erhardt, E Fernandes…

Index: Estevao, Monica S.; Carvalho, Luisa C.R.; Freitas, Marisa; Gomes, Ana; Viegas, Aldino; Manso, Joao; Erhardt, Stefan; Fernandes, Eduarda; Cabrita, Eurico J.; Marques, M. Manuel B. European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 823 - 833

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Citation Number: 19

Abstract

The close structural similarity between the two cyclooxygenase (COXs) isoforms and the absence of selective inhibitors without side effects continues to stimulate the development of novel approaches towards selective anti-inflammatory drugs. In the present study a small library of new indolic compounds involving two different substitutions patterns at the indole scaffold was synthesized. In order to establish a relation between the spatial distribution of ...