New Amides of 5??Acylamino??3??Methyl??4??Isothiazolecarboxylic Acid and their Immunotropic Activity

U Lipnicka, A Regiec, E Sułkowski…

Index: Lipnicka, Urszula; Regiec, Andrzej; Sulkowski, Emil; Zimecki, Michal Archiv der Pharmazie, 2005 , vol. 338, # 7 p. 322 - 328

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Citation Number: 5

Abstract

Abstract Several new amides 4 of 5-substituted 3-methyl-4-isothiazolecarboxylic acid were obtained. These compounds have acetylamino or benzoylamino groups in position 5 of the isothiazole ring. In position 4, the carboxylic group was transformed in the amides using amino-acid esters. Activities of the obtained derivatives were checked in the humoral immune response and delayed type hypersensitivity reaction to sheep red blood cells ( ...