Journal of heterocyclic chemistry

Preparation of dicarboxylate analogues of cerulenin

JD Moseley, J Staunton

Index: Moseley, Jonathan D.; Staunton, James Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 5 p. 819 - 830

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Citation Number: 3

Abstract

Abstract We have proposed and synthesized several new structural classes of Cerulenin analogues, which have potential as inhibitors of both fatty acid and polyketide synthase multi- enzyme complexes. These analogues contain cis epoxides bearing flanking carboxylate groups. Our syntheses have been designed to allow access to a wide range of fatty acid and polyketide-like side chains from readily available starting materials in convergent fashion ...