Enantioselective hydrogenation of β-keto sulfones with chiral Ru (II)-catalysts: Synthesis of enantiomerically pure butenolides and γ-butyrolactones

P Bertus, P Phansavath, V Ratovelomanana-Vidal…

Index: Bertus; Phansavath; Ratovelomanana-Vidal; Genet; Touati; Homri; Hassine, B. Ben Tetrahedron Asymmetry, 1999 , vol. 10, # 7 p. 1369 - 1380

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Citation Number: 68

Abstract

A series of β-hydroxy sulfones were synthesized with high enantioselectivities via a new enantioselective ruthenium-catalyzed hydrogenation using MeO-BIPHEP as a ligand. Some β-hydroxy sulfones were used in the synthesis of optically active butenolides and γ- butyrolactones with high yields and enantioselectivities over 95%.

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