Structure-based design of sulfonamide-substituted non-peptidic HIV protease inhibitors
…, MN Janakiraman, LA Dolak, JP McGrath
Index: Skulnick; Johnson; Howe; Tomich; Chong; Watenpaugh; Janakiraman; Dolak; McGrath; Lynn; Horng; Hinshaw; Zipp; Ruwart; Schwende; Zhong; Padbury; Dalga; Shiou; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 26 p. 4968 - 4971
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Citation Number: 59
Abstract
The rapid and alarming spread of acquired immune deficiency syndrome (AIDS) has sparked an intense worldwide search for drugs to combat the causative agent of this disease, human immunodeficiency virus (HIV). The HIV protease enzyme is a particularly attractive target in this regard since it plays a key role in viral maturati0n. l Although a number of interesting compounds are in development, they are primarily peptide based ...
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[Skulnick, Harvey I.; Johnson, Paul D.; Aristoff, Paul A.; Morris, Jeanette K.; Lovasz, Kristine D.; Howe, W. Jeffrey; Watenpaugh, Keith D.; Janakiraman, Musiri N.; Anderson, David J.; Reischer, Robert J.; Schwartz, Theresa M.; Banitt, Lee S.; Tomich, Paul K.; Lynn, Janet C.; Horng, Miao-Miao; Chong, Kong-Teck; Hinshaw, Roger R.; Dolak, Lester A.; Seest, Eric P.; Schwende, Francis J.; Rush, Bob D.; Howard, Gina M.; Toth, Lisa N.; Wilkinson, Karen R.; Kakuk, Thomas J.; Johnson, Carol W.; Cole, Serena L.; Zaya, Renee M.; Zipp, Gail L.; Possert, Peggy L.; Dalga, Robert J.; Zhong, Wei-Zhu; Williams, Marta G.; Romines, Karen R. Journal of Medicinal Chemistry, 1997 , vol. 40, # 7 p. 1149 - 1164]