1-Aryl-2-pyridyl-3, 4-dihydronaphthalenes: photofluorogenic ligands for the estrogen receptor

…, KE Carlson, JA Katzenellenbogen

Index: Scribner, Andrew W.; Haroutounian, Serkos A.; Carlson, Kathryn E.; Katzenellenbogen, John A. Journal of Organic Chemistry, 1997 , vol. 62, # 4 p. 1043 - 1057

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Citation Number: 16

Abstract

Three 1, 2-substituted-3, 4-dihydronaphthalenes that are pyridine analogs of the antiestrogen desmethylnafoxidine were prepared and evaluated as fluorescent ligands for the estrogen receptor. These compounds represent a class of fluorescent probes that we term “photofluorogenic”, denoting their ability to exist initially as a high affinity though weakly fluorescent stilbazole form which can be photocyclized-oxidized to a highly fluorescent ...