Highly Alpha??Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides

…, YS Peng, CT Ren, CY Wu, CH Wong

Index: Hsu, Che-Hsiung; Chu, Kuo-Ching; Lin, Yih-Shyan; Han, Jeng-Liang; Peng, Yu-Shiang; Ren, Chien-Tai; Wu, Chung-Yi; Wong, Chi-Huey Chemistry - A European Journal, 2010 , vol. 16, # 6 p. 1754 - 1760

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Citation Number: 85

Abstract

N-Acetyl neuraminic acid (Neu5Ac) is most frequently found at the terminal end of glycoconjugates on the cell surface. This terminally exposed position allows Neu5Ac- containing conjugates to be exploited as receptors for viruses and bacteria, in addition to governing a wide variety of biological processes, such as tumor metastasis, cell differentiation, and cell–cell interactions.[1] In naturally occurring sialosides, Neu5Ac is ...