A convenient synthesis of 4-aryl-1, 8-naphthyridin-2 (1H)-ones by the Suzuki coupling

H Ban, M Muraoka, N Ohashi

Index: Ban, Hitoshi; Muraoka, Masami; Ohashi, Naohito Tetrahedron Letters, 2003 , vol. 44, # 32 p. 6021 - 6023

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Citation Number: 16

Abstract

1,8-Naphthyridin-2(1H)-ones 1 are a group of compounds possessing antibacterial, 2 antiinflammatory, 3 antiallergic, or antisecretory activites. 4 Among them, 4-aryl-1,8-naphthyridin -2(1H)-ones have recently attracted considerable interests: we examined acyl-CoA: cholesterol acyltransferase (ACAT) inhibitory activity 5 and developed SL-7665; Yamanouch group developed YM-10335 possessing phosphodiesterase inhibitory activity 6., and (Fig. 1).