Synthesis and biological activity of some unsaturated 6-azauracil acyclonucleosides

Y Kabbaj, HB Lazrek, JL Barascut…

Index: Kabbaj, Youssef; Lazrek, Hassan Bihi; Barascut, Jean Louis; Imbach, Jean Louis Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 3 p. 161 - 172

Full Text: HTML

Citation Number: 20

Abstract

A useful route is described for obtaining Z and E unsaturated alkylating agents 3 and 4. Coupling 6-azauracils 5 and 6 with unsaturated alkylating agent followed by the deprotection with H+ resin gave acyclonucleosides 11–14 in good overall yields. Unsaturated acyclonucleosides phosphonates 19 and 20 were prepared using potassium carbonate as base and 4-bromobut-2-enyl diethyl phosphonate 16 as the alkylating agent. ...

Related Articles:

Pd (0)-catalyzed iodoalkynation of norbornene scaffolds: the remarkable solvent effect on reaction pathway

[Wang, Jianping; Tong, Xiaofeng; Xie, Xiaomin; Zhang, Zhaoguo Organic Letters, 2010 , vol. 12, # 23 p. 5370 - 5373]

Synthesis of nitrogen-or oxygen-containing ring systems by palladium-catalyzed intramolecular olefin allylations

[Oppolzer, W.; Gaudin, J.-M.; Bedoya-Zurita, M.; Hueso-Rodriguez, J.; Raynham, T. M.; Robyr, C. Tetrahedron Letters, 1988 , vol. 29, # 37 p. 4709 - 4712]

Synthesis of α-kainic acid and α-allokainic acid by Pd (0) mediated olefin insertion-carbonylation reaction

[Yoo, Sung-Eun; Lee, Sang-Hee; Yi, Kyu-Yang; Jeong, Nakcheol Tetrahedron Letters, 1990 , vol. 31, # 47 p. 6877 - 6880]

More Articles...