Synthesis, antitumor activity, and electrochemical behavior of some piperazinyl amidrazones

RJ Abdel-Jalil, EQ El Momani, M Hamad…

Index: Abdel-Jalil, Raid Jamil; El Momani, Ehab Q.; Hamad, Muawiah; Voelter, Wolfgang; Mubarak, Mohammad S.; Smith, Bianna H.; Peters, Dennis G. Monatshefte fur Chemie, 2010 , vol. 141, # 2 p. 251 - 258

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Citation Number: 21

Abstract

Abstract New piperazinyl amidrazones have been synthesized by direct interaction of the corresponding aryl hydrazones with the appropriate piperazine. On the basis of preliminary screening data for these new compounds, the antitumor activity of 1-(4-methylpiperazin-1-yl)- 1, 2-propandione 1-[2-(4-chlorophenyl) hydrazone] and 1-(4-ethylpiperazin-1-yl)-1, 2- propandione 1-[2-(4-chlorophenyl) hydrazone] was evaluated. Mean 50% growth ...