New efficient method for the total synthesis of (S, S)-isodityrosine from natural amino acids

ME Jung, TI Lazarova

Index: Jung, Michael E.; Lazarova, Tsvetelina I. Journal of Organic Chemistry, 1999 , vol. 64, # 9 p. 2976 - 2977

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Citation Number: 88

Abstract

Isodityrosine2 (1), isolated in the early 1980s from extensin, a plant cell wall glycoprotein, is the key structural unit which defines a large class of biologically active natural products. Piperazinomycin3 (2a) exhibits antimicrobial and antifungal activity, the cyclic tripeptide K- 134 (2b) is a potent inhibitor of angiotensin I converting enzyme (ACE), and OF4949-I- OF4949-IV5 (2crf) are inhibitors of aminopeptidase B and exhibit antitumor and ...