Tetrahedron

The total synthesis and biological evaluation of nafuredin-γ and its analogues

T Nagamitsu, D Takano, M Seki, S Arima, M Ohtawa…

Index: Nagamitsu, Tohru; Takano, Daisuke; Seki, Miyuki; Arima, Shiho; Ohtawa, Masaki; Shiomi, Kazuro; Harigaya, Yoshihiro; Omura, Satoshi Tetrahedron, 2008 , vol. 64, # 35 p. 8117 - 8127

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Citation Number: 12

Abstract

Nafuredin (1) is converted to nafuredin-γ (2) under mild basic conditions and both compounds exhibit the same inhibitory activity and selectivity against NADH-fumarate reductase (complex I). The total synthesis of 2 was achieved by a convergent approach using Stille coupling. The structural elements required for inhibitory activity against NADH- fumarate reductase (complex I) were then investigated by evaluation of nafuredin-γ (2) ...

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