18F-Glyco-RGD peptides for PET imaging of integrin expression: efficient radiosynthesis by click chemistry and modulation of biodistribution by glycosylation

S Maschauer, R Haubner, T Kuwert…

Index: Maschauer, Simone; Haubner, Roland; Kuwert, Torsten; Prante, Olaf Molecular Pharmaceutics, 2014 , vol. 11, # 2 p. 505 - 515

Full Text: HTML

Citation Number: 33

Abstract

Glycosylation frequently improves the biokinetics and clearance properties of macromolecules in vivo and could therefore be used for the design of radiopharmaceuticals for positron emission tomography (PET). Recently, we have developed a click chemistry method for 18F-fluoroglycosylation of alkyne-bearing RGD-peptides targeting the integrin receptor. To investigate whether this strategy could yield an 18F-labeled RGD ...

Related Articles:

1, 6-Anhydro-1-thio-β-D-glucopyranose (Thiolevoglucosan) and the Corresponding Sulfoxides and Sulfone

[Budesinsky, Milos; Polakova, Jana; Hamernikova, Michaela; Cisarova, Ivana; Trnka, Tomas; Cerny, Miloslav Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 3 p. 311 - 336]

Justus Liebig's Annalen Der Chemie. Über die Einwirkung des Ozons auf organische Verbindungen

[Helferich; Klein Justus Liebigs Annalen der Chemie, 1926 , vol. 450, p. 219,228 Justus Liebigs Annalen der Chemie, 1927 , vol. 455, p. 173,178]

Justus Liebig's Annalen Der Chemie. Über die Einwirkung des Ozons auf organische Verbindungen

[Helferich; Klein Justus Liebigs Annalen der Chemie, 1926 , vol. 450, p. 219,228 Justus Liebigs Annalen der Chemie, 1927 , vol. 455, p. 173,178]

Synthesis of sulfur-linked analogues of nigerose, laminarabiose, laminaratriose, gentiobiose, gentiotriose, and laminaran trisaccharide Y

[Contour-Galcera, Marie-Odile; Guillot, Jean-Michel; Ortiz-Mellet, Carmen; Pflieger-Carrara, Francoise; Defaye, Jacques; Gelas, Jacques Carbohydrate Research, 1996 , vol. 281, # 1 p. 99 - 118]

More Articles...