Structures of the major metabolites of meprobamate

BJ Ludwig, JF Douglas, LS Powell…

Index: Ludwig,B.J. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 3, p. 53 - 64

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Citation Number: 29

Abstract

Meprobamate (I) was found by Bergerl and others2 to be excreted in the urine of animals and humans in an unchanged form, and as a glucosyluronide conjugate. More recently, Walkenstein et aL3 reported the isolatJion of a second metabolic product, 2-hydroxymethyl- 2-propyl-1, 3-propanediol dicarbamate (11), from urine of animals receiving this drug. As part of our study of the metabolism of mepr~ bamate,~ we had occasion to synthesize the ...