Reactivity of N??1??(2, 2??dichloroalkylidene) amides

ND Kimpe, R Verhé, LD Buyck…

Index: De Kimpe,N. et al. Bulletin des Societes Chimiques Belges, 1976 , vol. 85, p. 763 - 779

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Abstract

Abstract A general synthetic route to N-1-(2, 2-dichloroalkylidene) amides is described, starting from aliphatic 2, 2-dichloroaldehydes and an appropriate N-unsubstituted amide. The adducts thus formed were converted into N-(1, 2, 2-trichloroalkyl) amides with thionylchloride and subsequently dehydrohalogenated with triethylamine. These N-acyl α, α- dichloroaldimines were found to be very apt to nucleophilic addition at the activated ...