Synthetic communications

Synthesis of 3, 4, 5-Trimethoxybenzaldehyde

PS Manchand, PS Belica, HS Wong

Index: Manchand, Percy S.; Belica, Peter S.; Wong, Harry S. Synthetic Communications, 1990 , vol. 20, # 17 p. 2659 - 2666

Full Text: HTML

Citation Number: 20

Abstract

Abstract The copper [I]-catalyzed exchange of bromine by methoxide in 5-bromovanillin and in 3, 5-dibromo-4-hydroxybenzaldehyde provides an efficient method for preparing 3, 5- dimethoxy-4-hydroxybenzaldehyde, from which 3, 4, 5-trimethoxybenzaldehyde is obtained by methylation with dimethylsulfate.