Chemical communications

Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics

KM Erixon, CL Dabalos, FJ Leeper

Index: Erixon, Karl M.; Dabalos, Chester L.; Leeper, Finian J. Chemical Communications, 2007 , # 9 p. 960 - 962

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Citation Number: 10

Abstract

Replacement of the thiazolium ring of thiamine pyrophosphate with a triazole gives extremely potent inhibitors of pyruvate decarboxylase from Z. mobilis, with KI values down to 20 pM; this system was used to explore pyrophosphate mimics and several effective analogues were discovered.