Synthesis of Some Quinolone Derivatives with Possible Local Anaesthetics Activities

AK Gupta, AK Agarwal…

Index: Gupta, Ajay Kumar; Agarwal; Mehra Asian Journal of Chemistry, 2012 , vol. 24, # 5 p. 2359 - 2360

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Abstract

Abstract Various new 7-[N-substituted acetyl amino]-2-methyl-4-quinolone were systheized by condensing 2-methyl-7-amino-4-quinolone with chloroacetyl chloride to get 2-methyl-7- chloroacetyl amino-4-quinolone, which on further reaction with various secondary amines to afford the required derivatives. The compounds were tested for their local anesthetic activity.