Total synthesis and biological evaluation of 22-hydroxyacuminatine

…, S Antony, Y Pommier, M Cushman

Index: Xiao, Xiangshu; Antony, Smitha; Pommier, Yves; Cushman, Mark Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1408 - 1412

Full Text: HTML

Citation Number: 44

Abstract

A total synthesis of 22-hydroxyacuminatine, a cytotoxic alkaloid isolated from Camptotheca acuminata, is reported. The key step in the synthesis involves the reaction of 2, 3-dihydro-1 H-pyrrolo [3, 4-b] quinoline with a brominated phthalide to generate a substituted pentacyclic 12 H-5, 11a-diazadibenzo [b, h] fluoren-11-one intermediate. Despite its structural resemblance to camptothecin and luotonin A, a biological evaluation of 22- ...

Related Articles:

Synthesis and biological activity of n-butylphthalide derivatives

[Wang, Wei; Cha, Xue-Xiang; Reiner, John; Gao, Yuan; Qiao, Hai-Ling; Shen, Jia-Xiang; Chang, Jun-Biao European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 1941 - 1946]

17O nuclear magnetic resonance spectroscopic study of substituted phthalic anhydrides and phthalides

[Canadian Journal of Chemistry, , vol. 65, p. 1214 - 1217]

Structure− activity relationships for a novel series of citalopram (1-(3-(dimethylamino) propyl)-1-(4-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile) analogues …

[Zhang, Peng; Cyriac, George; Kopajtic, Theresa; Zhao, Yongfang; Javitch, Jonathan A.; Katz, Jonathan L.; Newman, Amy Hauck Journal of Medicinal Chemistry, 2010 , vol. 53, # 16 p. 6112 - 6121]

Total synthesis and biological evaluation of 22-hydroxyacuminatine

[Journal of Medicinal Chemistry, , vol. 49, # 4 p. 1408 - 1412]

The regioselectivity of metal hydride reductions of 3-substituted phthalic anhydrides

[Journal of Organic Chemistry, , vol. 52, # 1 p. 129 - 134]

More Articles...