Synthesis, characterization and activity of new phosphonate dipeptides as potential inhibitors of VanX

…, CC Liu, L Feng, JM Xiao, LS Zhou, YL Zhang

Index: Jia, Chao; Yang, Ke-Wu; Liu, Cheng-Cheng; Feng, Lei; Xiao, Jian-Min; Zhou, Li-Sheng; Zhang, Yi-Lin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 482 - 484

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Citation Number: 2

Abstract

VanX, a Zn (II)-dependent D-ala-D-ala dipeptidase, is essential for vancomycin resistance in Enterococcus faecium. The enzymatic activity of VanX was previously found to be inhibited competitively by 2-{[(1-aminoethyl)(hydroxy) phosphoryl] oxy} propanoic acid (1B). Here ...