Synthesis and Biological Evaluation of Nitric Oxide??Donating Thalidomide Analogues as Anticancer Agents

T Wang, YH Zhang, XW Kong, YS Lai, H Ji…

Index: Wang, Tao; Zhang, Yi-Hua; Kong, Xiang-Wen; Lai, Yi-Sheng; Ji, Hui; Chen, Yan-Ping; Peng, Si-Xun Chemistry and Biodiversity, 2009 , vol. 6, # 4 p. 466 - 474

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Citation Number: 12

Abstract

In search of more potent anticancer agents, 15 nitric oxide (NO)-donating thalidomide analogues, 6a, 6b, 8a–8e, and 13a–13h, were designed and synthesized. Cytotoxicity of these compounds was evaluated in vitro against three human tumor cell lines (HepG2, A549, and PC-3). The results indicated that 13a–13d exhibited notable anticancer activities comparable to or stronger than that of 5-fluorouracil (5-FU). Structure–activity relationships ...

Acid-catalyzed nitronate cycloaddition reactions. Useful syntheses and simple transformations of 3-acyl-and 3-alkenylisoxazolines

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