Tetrahedron letters

A novel strategy for oligopeptide synthesis using a polymer-supported ammonium fluoride

M Kurosu, DC Crick

Index: Kurosu, Michio; Crick, Dean C. Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5325 - 5328

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Citation Number: 5

Abstract

A novel method for the preparation of oligopeptides with a PS-ammonium fluoride in the solution phase is reported. The synthesis of lipid II pentapeptide is efficiently synthesized via a PS-ammonium fluoride without chromatographic purifications. The method reported here is very convenient to synthesize a relatively large amount of oligopeptides with abundantly available Fmoc-protected amino acids in a time efficient manner.