Selectivity in binding a phenanthridinium-dinucleotide derivative to homopolynucleotides

RL Letsinger, ME Schott

Index: Letsinger, Robert L.; Schott, Margaret E. Journal of the American Chemical Society, 1981 , vol. 103, # 24 p. 7394 - 7396

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Citation Number: 87

Abstract

An oligonucleotide derivative possessing a structural feature that enhances binding of the oligomer to complementary sequences in a polynucleotide has interest as a potential site- specific inhibitor (or promoter) of enzymatic processes involving the polynucleotide. We describe in this Communication a model compound, 1, designed to test the concept that a fragment capable of intercalating in the base pair pockets of DNA can serve as such a ...