Tetrahedron

Short and efficient synthesis of (+)-subersic acids

P Basabe, A Diego, S Delgado, D Dı́ez, IS Marcos…

Index: Basabe, Pilar; Diego, Alberto; Delgado, Sergio; Diez, David; Marcos, Isidro S.; Urones, Julio G. Tetrahedron, 2003 , vol. 59, # 46 p. 9173 - 9177

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Citation Number: 26

Abstract

(−)-Subersic acid was isolated from the sponge Suberea sp. by Crews and co-worker. 1 The natural product was an inhibitor of human 15-lipoxygenase, assay that has been employed to discover new marine-sponge derived bioactive compounds. The availability of inhibitors could provide biomolecules that are useful as pharmacological agents. ... Recently Mori and co-workers 2 reported the synthesis and absolute configuration of (−)-subersic acid. The acid 1 was ...