Journal of Fluorine Chemistry

Facile synthesis of 1, 7, 8-trifluoro-2-naphthol via DMAP catalyzed cycloaromatization

K Araki, T Katagiri, M Inoue

Index: Araki, Keisuke; Katagiri, Tomohiro; Inoue, Munenori Journal of Fluorine Chemistry, 2014 , vol. 157, p. 41 - 47

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Citation Number: 3

Abstract

Abstract A facile synthesis of 1, 7, 8-trifluoro-2-naphthol, an important synthetic intermediate for liquid crystal compounds with a 1, 7, 8-trifluoronaphthalene structure, was developed starting from 4-bromo-1, 2-difluorobenzene via DMAP catalyzed intramolecular cycloaromatization in 51% overall yield for the 6 steps.