Isoprenoid (phosphinylmethyl) phosphonates as inhibitors of squalene synthetase

SA Biller, C Forster, EM Gordon, T Harrity…

Index: Biller; Forster; Gordon; Harrity; Scott; Ciosek Jr. Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 1869 - 1871

Full Text: HTML

Citation Number: 143

Abstract

In this paper, we describe our initial findings on the preparation and biological evaluation of isoprenoid (phosphinylmethy1) phosphonates (PMPs), stable analogues of farnesyl diphosphate (FPP, l), as inhibitors of squalene synthetase. Squalene synthetase14 catalyzes the reductive dimerization of two molecules of FPP to form squalene at the final branchpoint in the cholesterol biosynthesis pathway. Considering the recent clinical ...

Related Articles:

The synthesis of isoprenoid (phosphinylmethyl) phosphonates

[Biller, Scott A.; Forster, Cornelia Tetrahedron, 1990 , vol. 46, # 19 p. 6645 - 6658]

Enzymatic formation of pyrrole-containing novel cyclic polyprenoids by bacterial squalene: hopene cyclase

[Tanaka, Hideya; Noma, Hisashi; Noguchi, Hiroshi; Abe, Ikuro Tetrahedron Letters, 2006 , vol. 47, # 18 p. 3085 - 3089]

Enzymatic formation of pyrrole-containing novel cyclic polyprenoids by bacterial squalene: hopene cyclase

[Tanaka, Hideya; Noma, Hisashi; Noguchi, Hiroshi; Abe, Ikuro Tetrahedron Letters, 2006 , vol. 47, # 18 p. 3085 - 3089]

2, 3-Epoxy-10-aza-10, 11-dihydrosqualene, a high-energy intermediate analog inhibitor of 2, 3-oxidosqualene cyclase

[Ceruti, Maurizio; Balliano, Gianni; Viola, Franca; Grosa, Giorgio; Rocco, Flavio; Cattel, Luigi Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3050 - 3058]

Synthesis of rac-hippospongic acid A and revision of the structure

[Tokumasu, Munetaka; Ando, Hiroshi; Hiraga, Yoshikazu; Kojima, Satoshi; Ohkata, Katsuo Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 4 p. 489 - 496]

More Articles...