In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave??Assisted Flow Format

TO Painter, PD Thornton, M Orestano…

Index: Painter, Thomas O.; Thornton, Paul D.; Orestano, Mario; Santini, Conrad; Organ, Michael G.; Aube, Jeffrey Chemistry - A European Journal, 2011 , vol. 17, # 35 p. 9595 - 9598

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Citation Number: 21

Abstract

It is now well appreciated that flow techniques offer much in the area of fine organic synthesis.[1] In particular, they permit the utilization of even highly reactive intermediates in a relatively safe setting and offer a convenient means of preparing large quantities of compounds by extending the time of the flow reaction (“scaling out”) and thus avoiding issues with “scaling up” of batch reactions. Since some alkyl azides are known to pose ...

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