Synthesis and anti-Candida activity of novel 2-hydrazino-1, 3-thiazole derivatives

…, G Turan-Zitouni, P Fulcrand, F Demirci…

Index: Maillard, Ludovic T.; Bertout, Sebastien; Quinonero, Ophelie; Akalin, Guelsen; Turan-Zitouni, Guelhan; Fulcrand, Pierre; Demirci, Fatih; Martinez, Jean; Masurier, Nicolas Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1803 - 1807

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Citation Number: 21

Abstract

Eighteen new hydrazino-1, 3-thiazole derivatives were evaluated against 8 strains of multi- resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans ...