N, N'-Dialkyl-1, 2-bis (hydroxyphenyl) ethylenediamines and N, N'-dialkyl-4, 5-bis (4-hydroxyphenyl) imidazolidines. Syntheses and evaluation of their mammary tumor …

E Von Angerer, G Egginger, G Kranzfelder…

Index: Angerer, Erwin von; Egginger, Guenter; Kranzfelder, Gerhard; Bernhauer, Horst; Schoenenberger, Helmut Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 832 - 837

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Citation Number: 42

Abstract

K,= 1.1 X lo6)], C, H9 [(&)-5e, K,= 3.6 X lo6], and CSHll [(*)-5h, K,= 2.2 X lo6] showed a marked affinity, which is mainly due to the (+) enantiomers [eg,(+)-5e, K,= 2.1 X lo7]. No enhancement of affinity by cyclization to imidazolidines [eg,(f)-trans-7a, K,= 1.2 X lo7] was observed. These compounds [eg,(&)-,(+)-, and (-)-5e], which did not produce any uterine response in the mouse, were able to inhibit weakly the growth of the DMBA-induced ...