Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases

…, G Maga, F Focher, ER Smith, S Spadari…

Index: Xu; Maga; Focher; Smith; Spadari; Gambino; Wright Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 49 - 57

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Citation Number: 40

Abstract

Two series of selective inhibitors of herpes simplex virus types 1 and 2 (HSV1, 2) thymidine kinases (TK) have been developed as potential treatment of recurrent virus infections. Among compounds related to the potent base analog W-[m-(trifluoromethyl) phenyl] guanine (mCF3-PG), none was a more potent inhibitor than mCF3PG itself. Compounds related to the nucleoside W-phenyl-2'-deoxyguanosine (PhdG), but with alkyl, hydroxyalkyl, and ...

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