Nucleotides. Part XXVI.. A new synthesis of 9??(′??D??ribofuranosyl) uric acid and its 5′??monophosphate

BS Schulz, W Pfleiderer

Index: Schulz, Bernd S.; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1987 , vol. 70, p. 210 - 218

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Citation Number: 9

Abstract

Abstract Syntheses for 9-(β-D-ribofuranosyl) uric acid (16) and its 5′-monophosphate 14 have been achieved starting from guanosine and applying the 2-(p-nitrophenyl) ethyl group for protection of the aglycon moiety as well as the phosphate function. A more efficient and direct approach to 14 uses O 6, O 8-dibenzyl protection and phosphorylation by the Yoshikawa procedure. The various protected intermediates have been characterized by ...