Antimycobacterial activity of a series of pyrazinoic acid esters

MH Cynamon, SP Klemens, TS Chou…

Index: Cynamon, Michael H.; Klemens, Sally P.; Chou, Tso-Sheng; Gimi, Rayomand H.; Welch, John T. Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1212 - 1215

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Citation Number: 89

Abstract

A series of pyrazinoic acid esters has been prepared and evaluated for in vitro antimycobacterial activity. Several of the pyrazinoate esters have substantially better activity than the first-line antituberculous agent pyrazinamide against susceptible isolates of Mycobacterium turberculosis as well as activity against pyrazinamide-resistant isohtea. The minimal inhibitory concentrations (MICs) were lower for each organism and at each pH ...