Improved alkylation and product stability in phosphotriester formation through quinone methide reactions with dialkyl phosphates
…, MC McIntosh, KD Turnbull
Index: Bakke, Brian A.; McIntosh, Matthias C.; Turnbull, Kenneth D. Journal of Organic Chemistry, 2005 , vol. 70, # 11 p. 4338 - 4345
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Citation Number: 13
Abstract
Investigating reactions of functionalized p-quinone methides continues to advance our design of a reagent being developed for controlled, in situ modification of DNA via phosphodiester alkylation. Previously reported investigations of p-quinone methides derived from catechols allowed for trapping of isolable trialkyl phosphates for characterization and mechanistic information. However, lactone formation with these derivatives required long ...
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