Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation

…, CG Evans, LN Makley, JE Gestwicki…

Index: Evans, Christopher G.; Jinwal, Umesh K.; Makley, Leah N.; Dickey, Chad A.; Gestwicki, Jason E. Chemical Communications, 2011 , vol. 47, # 1 p. 529 - 531

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Citation Number: 22

Abstract

Nine neurodegenerative disorders are caused by the abnormal expansion of polyglutamine (polyQ) regions within distinct proteins. Genetic and biochemical evidence has documented that the molecular chaperone, heat shock protein 70 (Hsp70), modulates polyQ toxicity and