Canadian Journal of Chemistry

Echange isotopique hydrogène-deutérium subi par les groupements méthyles de la triméthyl-4, 5, 6 pyrimidone-2

E Picquenard, P Dizabo

Index: Picquenard, Eric; Dizabo, Pierre Canadian Journal of Chemistry, 1981 , vol. 59, p. 1270 - 1276

Full Text: HTML

Citation Number: 4

Abstract

The rate of deuterium exchange of 4 and 6 methyl protons in 4, 5, 6-trimethyl-2-pyrimidone has been followed in D2O over a range of acidity from pD 0.4 to 7.7 by means of proton magnetic resonance spectroscopy. The maximum of exchange rate represents equimolar proportions of the pyrimidone and its conjugate acid. The maximum is due to the neutral molecule acting as a base and removing a proton from one of the methyl groups of its ...