Nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro (trimethylsilyl) methylphosphonate

AV Alexandrova, P Beier

Index: Alexandrova, Anastasia V.; Beier, Petr Journal of Fluorine Chemistry, 2009 , vol. 130, # 5 p. 493 - 500

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Citation Number: 18

Abstract

A new nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro (trimethylsilyl) methylphosphonate (1) has been achieved. The reactive carbanion species were generated under mild reaction conditions with a catalytic amount of initiator. This methodology was compatible with non-enolizable and in some cases with enolizable aldehydes and ketones and provided a straightforward access to phosphates of syn and ...