Synthesis of new substituted 4, 5-dihydro-3h-spiro [1, 5]-benzoxazepine-2, 4′-piperidine and biological properties

…, N Pietrancosta, V Moret, S Marc, C Garino…

Index: Laras, Younes; Pietrancosta, Nicolas; Moret, Vincent; Marc, Sylvain; Garino, Cedrik; Rolland, Amandine; Monnier, Valerie; Kraus, Jean-Louis Australian Journal of Chemistry, 2006 , vol. 59, # 11 p. 812 - 818

Full Text: HTML

Citation Number: 6

Abstract

Abstract The reduction of substituted spiro-piperidinyl chromanone oximes with DIBAH reagents has been known to afford the corresponding substituted 4, 5-dihydro-3H-spiro [1, 5]- benzoxazepine-2, 4′-piperidine. The position and electronic effects of the substituents on the aryl moiety control the observed rearrangement. Spiro-benzoxazepine analogue 5j represents a key intermediate for the creation of a library of diverse potential bioactive ...