2, 4-Diaminothieno [2, 3-d] pyrimidine analogs of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate …

…, JE Wright, JH Freisheim, JJ Heusner…

Index: Rosowsky, Andre; Mota, Clara E.; Wright, Joel E.; Freisheim, James H.; Heusner, James J.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 21 p. 3103 - 3112

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Citation Number: 76

Abstract

A series of eight previously undescribed 2, 4-diaminothieno [2,341 pyrimidine analogues of the potent dihydrofolate reductase (DHFR) inhibitors trimetrexate (TMQ) and piritrexim (PTX) were synthesized as potential drugs against Pneumocystis carinii and Toxoplasma gondii, which are major causes of severe opportunistic infections in AIDS patients. 2, 4-Diamino- bmethy1-6-(aryl/aralkyl) thieno [2, 3-d] pyrimidines with 3, 4, 5-trimethoxy or 2, bdimethoxy ...