Tetrahedron

Botryodiplodin: a mycotoxin from penicillium roqueforti: Reaction with amino-pyrimidines, amino-purines and 2'-deoxynucleosides

F Renauld, S Moreau, A Lablache-Combier, B Tiffon

Index: Renauld, Frank; Moreau, Serge; Lablache-Combier, Alain; Tiffon, Bernard Tetrahedron, 1985 , vol. 41, # 5 p. 955 - 962

Full Text: HTML

Citation Number: 9

Abstract

Botryodiplodin is a mycotoxin isolated from a strain of Peicillium roqueforti. This toxin exhibits genotoxic properties, it inhibits cell metabolism at the level of replication, transcription and traduction; it induces DNA-protein cross-links. The chemical reaction with amino-pyrimidines and amino-purine has led to 2-aminooxolane compounds. The structure and the stereochemistry of these adducts have been studied. Likewise the reaction with ...