Tetrahedron

An efficient preparation of N-acetyl enamides catalyzed by Ru (II) complexes

K Murugan, D Huang, YT Chien, ST Liu

Index: Murugan, Kaliyappan; Huang, Da-Wei; Chien, Yu-Ting; Liu, Shiuh-Tzung Tetrahedron, 2013 , vol. 69, # 1 p. 268 - 273

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Citation Number: 7

Abstract

Reductive acetylation of ketoximes to give the corresponding acyl enamides can be achieved by using 1–3 mol% of [RuCl2 (p-cymene)] 2 as the catalyst in the presence of KI as the reducing agent in high yields. This procedure has been applied to synthesize N-[1-(1, 3- benzodioxol-5-yl)-1-butenyl] acetamide (6), which is the intermediate for the synthesis of DMP 777, an inhibitor of leukocyte elastase.

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