Synthesis and interfacial behavior of sulfur-containing analogs of lung surfactant dipalmitoyl phosphatidylcholine

…, Z Wang, RH Notter, Z Wang, L Qu, AL Schwan

Index: Chang, Yusuo; Wang, Zhengdong; Notter, Robert H.; Wang, Zhongyi; Qu, Long; Schwan, Adrian L. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5983 - 5986

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Citation Number: 13

Abstract

Synthesis methods and initial surface property characterizations are reported for two sulfur- containing phosphonolipids related structurally to dipalmitoyl phosphatidylcholine (DPPC), the major lung surfactant glycerophospholipid. Sulfur linkages in these compounds affect molecular interactions relative to ester linkages, and are structurally resistant to cleavage by phospholipases. The SO2-linked analog synthesized here had increased adsorption and ...